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Recombinant Human TGF Beta-2 (TGFB2)

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Product Code: Z103057
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TGF beta 2 belongs to the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types, transducing signals through combinations of accessory receptor betaglycan (also known as TGF-beta RIII) and type II ser/thr kinase receptors TGF-beta RII and TGF-beta RI or alternatively, ALK-1. Their downstream effectors the SMAD proteins regulates transcription upon phosphorylation and activation. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. TGF beta 2 is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Recombinant TGF beta 2 is expressed from human 293 cells as a mature disulfide-linked homodimer with a molecular mass of 25 kDa.