Recombinant Human VEGF (121aa)

VEGF is a homodimeric glycoprotein that is actively involved in angiogenesis, vasculogenesis and endothelial cell growth. Owing to alternative splicing of the mRNA, VEGF occurs in several molecular variants of 121, 162, 145, 148, 165, 183, 189 and 206 amino acids. The various isoforms of VEGF differ in biological properties such as: (a) the receptors they recognize and (b) their interaction with heparan sulfate proteoglycans. VEGF-121 and VEGF-165 are soluble secreted forms of the factor while VEGF-189 and VEGF-206 are mostly bound to heparin-containing proteoglycans in the cell surface or in the basement membrane. VEGF121 is a potent growth and angioenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis amd vascular permeability. Recombinant Human VEGF (121aa) expressed in human 293 cells as a glycosylated cytokine with a molecular mass of 37 kDa as dimer and 50 kDa as trimer.