Recombinant Human pro-IGF-II

Insulin-like growth factor 2 (IGF2) is one of the mitogenic, polypeptide growth factors that belongs to the insulin family, due to its structural and functional similarity to insulin. IGF2 is mainly produced in the liver and several other tissues at certain times. IGF2 expression can be found in many tissues usually with autocrine, paracrine and endocrine functions, and mainly acts as a growth promoting hormone during gestation. The pro-IGF-II proteins make up 10-20% of circulating IGF2 and is converted to mature IGF2 by sequential cleavage at amino acids 104, 87 and 67. Pro-IGF-II proteins are secreted by some tumour cell lines and levels are elevated in non-islet cell tumour hypoglycaemia. Recombiant Human pro-IGF-II is expressed in human 293 cells as a monomeric glycoprotein with a molecular mass of 25 kDa.