Recombinant Human IL10
- Product Code: Z102835
- Availability: In Stock
IL10 is a homodimeric protein with subunits having a length of 160 amino acids. In human system IL10 is produced by activated CD8(+) peripheral blood T cells, by T helper CD4(+) T cell clones after both antigen-specific and polyclonal activation, by B cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides and mast cells. IL10 down-regulates the function of Th1 and Th2 cells. IL10 inhibits the synthesis of a number of cytokines such as IFN-gamma, IL2 and TNF-beta in Th1 T helper subpopulations of T cells but not of Th2 T helper cells. This activity is antagonized by IL4. The inhibitory effect on IFN-gamma production is indirect and appears to be the result of a suppression of IL12 synthesis by accessory cells. Recombinant Human IL10 is expressed in human 293 cells as a non-covalent homodimeric glycoprotein
with a molecular mass of 17 kDa.